Asymmetric catalysis


Merging enamine catalysis with hard metal Lewis acid catalysis offers great potential for new carbon-carbon and carbon-heteroatom bond-forming reactions. The major barrier hindering the growth of this area lies in the acid-base quenching reaction leading to catalyst inactivation. We are interested in developing new strategies and new catalytic systems to solve the acid-base quenching problem. Using these strategies and catalytic systems, we aim to develop asymmetric organic transformations that cannot be achieved by organocatalysis and metal catalysis independently.


Representative Publications



1. Jacqkis Davis, Jose Cortes Vazquez, Vladimir N. Nesterov, Weiwei Luo† and Hong Wang*

submitted to ACS Catalysis, 2022.

2. Weiwei Luo, Zhicheng Sun, E. H. Nisala Fernando, Vladimir N. Nesterov, Thomas R. Cundari* and Hong Wang*

Chem. Sci., 2020,11, 9386-9394.

3. Weiwei Luo, Zhicheng Sun, E. H. Nisala Fernando, Vladimir N. Nesterov, Thomas R. Cundari* and Hong Wang*

ACS Catal., 2019, 9(9), 8285-8293.

4. Y. Deng, L. Liu, R. G. Sarkisian, K. Wheeler, H. Wang,* Z. Xu*

Angew. Chem. Int. Ed. 2013, 52, 3663–3667.

5. Z. Xu, L. Liu, K. Wheeler, H. Wang*,

Angew. Chem. Int. Ed, 2011, 50, 3484-3488.

6. Y. Deng, S. Kumar and H. Wang,

Chem. Commun. 2014, 50, 4272-4284.

department of energy